Protective Effect of Co Q10 and Candesartan on Bleomyycin Induced Lung Fibrosis in Rats

Fibrosis of the lungs is final phase many lung illnesses. Its characterized by excessive matrix production leading to normal architecture destruction and eventually death. CoQ10 an essential constituent membrane oxidoreductase System. It intracellularly localized antioxidant
 
 enzyme that endogenously synthesized in humans. protects cellular components from free radical-induced oxidative damage. candesartan a selective antagonist angiotensin II type 1 receptor (AT1) widely employed for treatment hypertension. Most up date research shows close involvement with damage fibrosis process tissues organs circulation.
 Objective: This animal study was designed investigate effect Co Q10 as antifibrotic agents against pulmonary focusing on selected markers involved fibrosis.
 Materials Method: 48 rats divided randomly into four groups, each consisting 12 male rats. Group I: (Control group), this group received single injection 0.2 ml saline via intratracheal route. II: (The BLM (8.3 U/kg) dose rout. III: (BLM+CoQ10 group) receive sulfate salt dissolved 0.1 instillation concomitant 100 mg/kg co Q 10 per day orally 5 days before after injection. IV: (BLM+ (10 mg/kg) The studied serum biomarkers were glutathione, arachidonate lipoxygenase addition histopathological examination using trichrome stain.
 Results: GSH concentration lower comparison control CoQ10) but difference not statistically significant. levels showed significant(P<0.05) elevation Candesartan) when compared group. ALOX5 significantly elevated (P < 0.05). highly (BLM +CoQ10) 0.01) very 0.001) comparing it furthermore, histologically reduction numbers inflammation cells decrease induced bleomycin.
 Conclusion: bleomycin